Academic profile

Masamitsu Yamaguchi
Professor
Department of Applied Biology
Insect Biomedical Research Center
Kyoto Institute of Technology
Matsugasaki, Sakyo-ku
Kyoto 606-8585, Japan
E-mail: myamaguc@kit.ac.jp
Phone: +81 75 724 7781

Education (from Bachelors degree)
BSc 1977 Kobe University Japan Biology
MSc 1979 Kobe University Japan Biology
PhD 1983 Osaka University Japan Medical Science
Positions held
2001-present, Department of Applied Biology, Kyoto Institute of Technology, Professor, Molecular Genetics.
2006-2007, Head of Department, Department of Applied Biology, Kyoto Institute of Technology
1994-2001, Aichi Cancer Center Research Institute, Section Head, Cell Biology.
1985-1994, Aichi Cancer Center Research Institute, Senior Researcher, Cell Biology
1983-1985, Harvard Medical School, Department of Biological Chemistry Post Doctoral Fellow (Supervisor; Mel DePamphilis)

Research Interest
  1. A gene regulatory network of the transcription factor DREF in Drosophila.
  2. Studies on Drosophila DNA polymerase epsilon and the transcription factor NF-Y.
  3. Regulation of higher order structure of chromatin having special emphasis on G9a histone methyltransferase
  4. Development of Drosophila models for human diseases.
Main Publications
[2010]
  • Tue, N. T., Yoshioka, Y. and Yamaguchi, M.: NF-Y transcriptionally regulates the Drosophila p53 gene. Gene, in press.
  • Nagai, R., Hashimoto, R., Tanaka, Y., Taguchi, O., Sato, M., Matsukage, A. and Yamaguchi, M.: Syntrophin-2 is required for eye development in Drosophila. Exp. Cell Res. 316, 272-285, 2010.
  • Tue, N. T., Thao, D. T. P. and Yamaguchi, M.: Role of DREF in transcriptional regulation of the Drosophila p53 gene. Oncogene 29, 2060-2069, 2010.
  • Park, J.-S., Kim, Y.-S., Kim, J.-G., Lee, S.-H., Park, S.-Y., Yamaguchi, M. and Yoo, M.-A.: Regulation of the Drosophila p38b gene by the transcription factor DREF in adult midgut. Biochim. Biophys. Acta. 1799, 510-519, 2010.
  • Nagai, R., Hashimoto, R. and Yamaguchi, M.: Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. Exp. Cell Res. 316, 2313-2321, 2010.
[2009]
  • Ida, H., Suzusho, N., Suyari, O., Yoshida, H., Ohno, K., Hirose, F., Itoh, M. and Yamaguchi, M.: Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: Identification and characterization of HP6 as a novel target of DREF. Nucleic Acids Res. 37, 1423-1437, 2009.
  • Suyari, O., Ida, H., Yoshioka, Y., Kato, Y., Hashimoto, R. and Yamaguchi, M.: Identification of the Drosophila Mes4 gene as a novel target of the transcription factor DREF. Exp. Cell Res. 315, 1403-1414, 2009.
  • Puseenam A., Yoshioka Y., Nagai, R., Hashimoto R., Suyari, O., Itoh, M., Enomoto, A., Takahashi, M. and Yamaguchi, M.: A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size. Exp. Cell Res. 315, 3370-3380, 2009.
  • Kuraishi, T., Nakagawa, Y., Nagaosa, K., Hashimoto, Y., Ishimoto, T., Moki, T., Fujita, Y., Nakayama, H., Dohmae, N., Shiratsuchi, A., Yamamoto, N., Ueda, K., Yamaguchi, M., Awasaki, T. and Nakanishi, Y.: Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells. EMBO J. 28, 3868-3878, 2009.
[2008]
  • Yoshioka, Y., Suyari, O. and Yamaguchi, M.: Transcription factor NF-Y is involved in regulation of the JNK pathway during Drosophila thorax development. Genes to Cells, 13, 117-130, 2008.
  • Thao, D. T. P., Seto, H. and Yamaguchi, M.: Drosophila Myc is required for normal DREF gene expression. Exp. Cell Res. 314, 184-192, 2008.
  • Sugano, W., Ohno, K., Yoneda-Kato, N., Kato, J. and Yamaguchi, M.: The myeloid leukemia factor interacts with COP9 signalosome subunit 3 in Drosophila melanogaster. FEBS J. 275, 588-600, 2008.
  • Kato, Y., Kato, M., Tachibana, M., Shinkai, Y. and Yamaguchi, M.: Characterization of Drosophila G9a in vivo and identification of genetic interactants. Genes to Cells, 13, 703-722, 2008.
  • Nakamura, K., Ida, H. and Yamaguchi, M.: Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway. Nucleic Acids Res. 36, 3905-3915, 2008.
  • Mahalingam, M., Arvind, R., Ida, H., Murugan, A. K., Yamaguchi, M. and Tsuchida, N.: ERK2 CD domain mutation from human cancer cell line enhanced anchorage-independent cell growth and abnormality in Drosophila. Oncology Rep. 20, 957-962, 2008.
  • Fujikake, N., Nagai, Y., Popiel, A., Okamoto, Y., Yamaguchi, M. and Toda, T.: Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones. J. Biol. Chem. 283, 26188-26197, 2008.